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acc2 f f mice  (Jackson Laboratory)

 
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    Structured Review

    Jackson Laboratory acc2 f f mice
    ( A and B ) Total RNA was isolated from hearts of 10-week-old WT, ACC1 HKO, <t>ACC2</t> HKO, and ACC dHKO male mice, and quantitative RT-qPCR was performed to measure Acc1 and Acc2 mRNA expression. ***P < 0.001, ****P < 0.0001 by one-way ANOVA. ( C ) Hearts from 20-week-old WT and ACC dHKO female mice were harvested and freeze-clamped to measure malonyl-CoA and acetyl-CoA levels as described in Methods. ****P < 0.0001 by unpaired two-tailed Student’s t test. ( D–F ) ECHO assessment of cardiac function in male ACC1 HKO, ACC2 HKO, and ACC dHKO mice at 2, 4, 6, and 9 months of age.
    Acc2 F F Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/acc2 f f mice/product/Jackson Laboratory
    Average 86 stars, based on 1 article reviews
    acc2 f f mice - by Bioz Stars, 2026-05
    86/100 stars

    Images

    1) Product Images from "Unrestrained fatty acid oxidation triggers heart failure in mice via cardiolipin loss and mitochondrial dysfunction"

    Article Title: Unrestrained fatty acid oxidation triggers heart failure in mice via cardiolipin loss and mitochondrial dysfunction

    Journal: bioRxiv

    doi: 10.64898/2026.01.12.698694

    ( A and B ) Total RNA was isolated from hearts of 10-week-old WT, ACC1 HKO, ACC2 HKO, and ACC dHKO male mice, and quantitative RT-qPCR was performed to measure Acc1 and Acc2 mRNA expression. ***P < 0.001, ****P < 0.0001 by one-way ANOVA. ( C ) Hearts from 20-week-old WT and ACC dHKO female mice were harvested and freeze-clamped to measure malonyl-CoA and acetyl-CoA levels as described in Methods. ****P < 0.0001 by unpaired two-tailed Student’s t test. ( D–F ) ECHO assessment of cardiac function in male ACC1 HKO, ACC2 HKO, and ACC dHKO mice at 2, 4, 6, and 9 months of age.
    Figure Legend Snippet: ( A and B ) Total RNA was isolated from hearts of 10-week-old WT, ACC1 HKO, ACC2 HKO, and ACC dHKO male mice, and quantitative RT-qPCR was performed to measure Acc1 and Acc2 mRNA expression. ***P < 0.001, ****P < 0.0001 by one-way ANOVA. ( C ) Hearts from 20-week-old WT and ACC dHKO female mice were harvested and freeze-clamped to measure malonyl-CoA and acetyl-CoA levels as described in Methods. ****P < 0.0001 by unpaired two-tailed Student’s t test. ( D–F ) ECHO assessment of cardiac function in male ACC1 HKO, ACC2 HKO, and ACC dHKO mice at 2, 4, 6, and 9 months of age.

    Techniques Used: Isolation, Quantitative RT-PCR, Expressing, Two Tailed Test



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    ( A and B ) Total RNA was isolated from hearts of 10-week-old WT, ACC1 HKO, <t>ACC2</t> HKO, and ACC dHKO male mice, and quantitative RT-qPCR was performed to measure Acc1 and Acc2 mRNA expression. ***P < 0.001, ****P < 0.0001 by one-way ANOVA. ( C ) Hearts from 20-week-old WT and ACC dHKO female mice were harvested and freeze-clamped to measure malonyl-CoA and acetyl-CoA levels as described in Methods. ****P < 0.0001 by unpaired two-tailed Student’s t test. ( D–F ) ECHO assessment of cardiac function in male ACC1 HKO, ACC2 HKO, and ACC dHKO mice at 2, 4, 6, and 9 months of age.
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    ( A and B ) Total RNA was isolated from hearts of 10-week-old WT, ACC1 HKO, <t>ACC2</t> HKO, and ACC dHKO male mice, and quantitative RT-qPCR was performed to measure Acc1 and Acc2 mRNA expression. ***P < 0.001, ****P < 0.0001 by one-way ANOVA. ( C ) Hearts from 20-week-old WT and ACC dHKO female mice were harvested and freeze-clamped to measure malonyl-CoA and acetyl-CoA levels as described in Methods. ****P < 0.0001 by unpaired two-tailed Student’s t test. ( D–F ) ECHO assessment of cardiac function in male ACC1 HKO, ACC2 HKO, and ACC dHKO mice at 2, 4, 6, and 9 months of age.
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    ( A and B ) Total RNA was isolated from hearts of 10-week-old WT, ACC1 HKO, <t>ACC2</t> HKO, and ACC dHKO male mice, and quantitative RT-qPCR was performed to measure Acc1 and Acc2 mRNA expression. ***P < 0.001, ****P < 0.0001 by one-way ANOVA. ( C ) Hearts from 20-week-old WT and ACC dHKO female mice were harvested and freeze-clamped to measure malonyl-CoA and acetyl-CoA levels as described in Methods. ****P < 0.0001 by unpaired two-tailed Student’s t test. ( D–F ) ECHO assessment of cardiac function in male ACC1 HKO, ACC2 HKO, and ACC dHKO mice at 2, 4, 6, and 9 months of age.
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    Image Search Results


    ( A and B ) Total RNA was isolated from hearts of 10-week-old WT, ACC1 HKO, ACC2 HKO, and ACC dHKO male mice, and quantitative RT-qPCR was performed to measure Acc1 and Acc2 mRNA expression. ***P < 0.001, ****P < 0.0001 by one-way ANOVA. ( C ) Hearts from 20-week-old WT and ACC dHKO female mice were harvested and freeze-clamped to measure malonyl-CoA and acetyl-CoA levels as described in Methods. ****P < 0.0001 by unpaired two-tailed Student’s t test. ( D–F ) ECHO assessment of cardiac function in male ACC1 HKO, ACC2 HKO, and ACC dHKO mice at 2, 4, 6, and 9 months of age.

    Journal: bioRxiv

    Article Title: Unrestrained fatty acid oxidation triggers heart failure in mice via cardiolipin loss and mitochondrial dysfunction

    doi: 10.64898/2026.01.12.698694

    Figure Lengend Snippet: ( A and B ) Total RNA was isolated from hearts of 10-week-old WT, ACC1 HKO, ACC2 HKO, and ACC dHKO male mice, and quantitative RT-qPCR was performed to measure Acc1 and Acc2 mRNA expression. ***P < 0.001, ****P < 0.0001 by one-way ANOVA. ( C ) Hearts from 20-week-old WT and ACC dHKO female mice were harvested and freeze-clamped to measure malonyl-CoA and acetyl-CoA levels as described in Methods. ****P < 0.0001 by unpaired two-tailed Student’s t test. ( D–F ) ECHO assessment of cardiac function in male ACC1 HKO, ACC2 HKO, and ACC dHKO mice at 2, 4, 6, and 9 months of age.

    Article Snippet: Acc2 f/f mice were purchased from The Jackson Laboratory (stock no. 013042; B6N;129S- Acacb tm1.1Lowl /J).

    Techniques: Isolation, Quantitative RT-PCR, Expressing, Two Tailed Test